Hence, the aim of the present study was to evaluate, for the first time, the compatibility of RA with excipients commonly used in solid dosage forms, by DSC, TG, FTIR, ssNMR and IST.
Hence, the aim of the present study was to evaluate, for the first time, the compatibility of RA with excipients commonly used in solid dosage forms, by DSC, TG, FTIR, ssNMR and IST. When formulating challenging molecules into solid oral dosage forms, polymeric pharmaceutical excipients permit masking undesired physicochemical properties of drugs and consequently, altering their pharmacokinetic profiles to improve the therapeutic effect. Apart from the drug’s active ingredient, other essential components include diluents or fillers, binders, disintegrants, lubricants, coloring agents and preservatives (3).
This chapter highlights the excipient properties that impact the performance of an excipient and provides general guidelines on their usage with greater emphasis on physical properties of an excipient.
Various excipients used in solid dosage forms perform various functions like:- Binders, diluents, lubricants, disintegrating agent’s plasticizers etc, e.g. Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability Enteric coating is a common procedure in the development of oral pharmaceutical dosage forms. Concave meniscus is produced when adhesion energy, visualized via liquid being attracted to the walls of a capi- excipients for prescription and over-the-counter oral solid dosage form (OSDF) pharmaceutical applications. Razboršek (2011) demonstrated the stability of RA powder under different conditions, but its compatibility with excipients employed in the formulation of solid dosage forms remains unexplored. Excipients, which are an integral part of any formulation, can significantly impact stability, processability, and performance of a dosage form. The main advantage of enteric coating is that it protects the drug from acidic pH and enzymatic degradation in the stomach while protecting it from the undesirable effects of some drugs. Coprocessed Excipients for Solid Dosage Forms Satish K.Nachaegari and Arvind K.Bansal* Arvind K. Bansal, PhD, is an associate professor in the Department of Pharmaceutical Technology (Formulations), National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Solid Dosage Forms Tablets, capsules, sachets and suppositories . Excipients play a central role in the drug development process, in the formulation of stable dosage forms and in their administration. COMPATIBILITY STUDIES BETWEEN PIROXICAM AND PHARMACEUTICAL EXCIPIENTS USED IN SOLID DOSAGE FORMS H. K. Stulzer,1, 2,* M. P. Tagliari,1 A. Topical semi-solid dosage forms are normally presented in the form of creams, gels, ointments, or pastes. J. of Pharm. The objective of this study was to predict the effect of formulation on the dissolution rate of a poorly soluble drug using computer simulations. They contain one or more active ingredients dissolved or uniformly dispersed in a suitable base and any suitable excipients such as emulsifiers, viscosity-increasing agents, antimicrobial agents, antioxidants, or stabilizing agents. Nagar, Punjab-160062, INDIA, tel. (IJPLS), Vol. & Life Sci. … Used in tablets and capsules. ... precise metering & handling in preparation of dosage forms. Surface active agents as excipients in semi-solid dosage forms Romanian Biotechnological Letters, Vol. The excipients used in solid oral-dosage forms are available from various sources and a variety of grades, he says.
Oral administration of solid dosage forms (e.g., tablets and capsules) is the most common and convenient route of drug administration. 1, 2015 10261 capillary tube with a convex or concave meniscus being formed. The present review fo cus on such newer Excipients which have proved their potential in developing efficient solid dosage forms. 2, Issue 8: Aug.: 2011, 1006-1019 1006 INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES New pharmaceutical excipients in solid dosage forms – A review Hardik Patel * , Viral Shah and Umesh Upadhyay Department of … Excipients in solid_dosage_forms 1. Review Article [Patel et al., 2(8): Aug., 2011] ISSN: 0976-7126 Int. Semi-Solid Dosage Form Semi-solids are formulated as creams, ointments, gels, transdermal patches, and suppositories. In many products, excipients make up the bulk of the total dosage form (1).
A part of Kline’s global analysis of the specialty excipient markets, grouping five excipients categories: - Specialty binders and fillers - Disintegrants - Lubricants - Coatings - Specialty excipients used in matrix delivery systems Merck's expertise and support make it possible to provide you with a selected range of actives and auxiliaries. A list of Pharmaceutical Excipients used in pharmaceutical preparations Fillers.
Excipients play an important role in the formulation of dosage forms and can be used to improve the bioavailability of a drug through physical interactions that alter the rate of dissolution of a drug. Kolliwax ® S Fine can be used for various oral solid as well as semi-solid dosage forms: It can be used as a lubricant in oral dosage forms, matrix forming agent in sustained-release dosage forms, emulsifying and solubilizing agent in topical formulations and hardening agent in glycerin suppositories. Razboršek (2011) demonstrated the stability of RA powder under different conditions, but its compatibility with excipients employed in the formulation of solid dosage forms remains unexplored.